Trivalent Chromium Modulates Hexosamine Biosynthesis Pathway Transcriptional Activation of Cholesterol Synthesis and Insulin Resistance
نویسندگان
چکیده
منابع مشابه
Hexosamine biosynthesis pathway ( HBP )
27 There is increasing evidence that endoplasmic reticulum (ER) stress contributes to the 28 development atherosclerosis in diabetes mellitus. The purpose of this study was to determine the effects 29 of increased hexosamine biosynthesis pathway (HBP) flux on ER stress levels and the complications of 30 ER stress associated with diabetes and atherosclerosis in hepatic cells. Glutamine:fructose-...
متن کاملChromium and insulin resistance.
Insulin resistance leads to the inability of insulin to control the utilization and storage of glucose. It is associated initially with elevated levels of circulating insulin followed by glucose intolerance which may progress to type 2 diabetes, hyperlipidaemia, hypertension, obesity and cardiovascular diseases. While the causes of these diseases are multifactorial, one nutrient that is associa...
متن کاملEffects of probiotic Lactobacillus paracasei TD3 on moderation of cholesterol biosynthesis pathway in rats
Objective(s): Prevalence of high-fat food consumption, such as fast foods is one of the major causes of hypercholesterolemia, which can lead to cardiovascular diseases. 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and cytochrome P450 7A1 (CYP7A1) are two key genes in cholesterol metabolism. Use of probiotics in the diet is a promising approach for modulation...
متن کاملFree fatty acids induce peripheral insulin resistance without increasing muscle hexosamine pathway product levels in rats.
To evaluate the role of the hexosamine biosynthesis pathway (HBP) in fat-induced insulin resistance, we examined whether fat-induced insulin resistance is additive to that induced by increased HBP flux via glucosamine infusion and, if so, whether such additive effects correlate with muscle HBP product levels. Prolonged hyperinsulinemic (approximately 550 pmol/l) euglycemic clamps were conducted...
متن کاملPerformance Properties of Trivalent Chromium
A trivalent chromium electroplating process has been io use commercially in North America since its introduction in 1975. Based upon years of laboratory and in-plant experience and testing, many process performance characteristics and physical properties of deposits have been determined. This paper compares the performance of trivalent chromium with hexavalent chromium processes. Factors such a...
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ژورنال
عنوان ژورنال: Open Journal of Endocrine and Metabolic Diseases
سال: 2013
ISSN: 2165-7424,2165-7432
DOI: 10.4236/ojemd.2013.34a1001